Fachbereich Informatik
Gliederung
Fachbereich Informatik, Institut für funktionale Gen-Analytik (IFGA)
Standort
Sankt Augustin
Raum
C 255
Adresse
Grantham-Allee 20
53757, Sankt Augustin
Telefon
+49 2241 865 281Profil
Forschungsgebiete
- Bioinformatik & Chemoinformatik
- Data Science, Machine Learning
- Graph and Optimization Algorithms for Big Data
- Algorithms and Data Analysis in Natural Sciences
Funktionen (aktuell)
- Lehrplanung Fachbereich Informatik
- Vorsitzender Studienbeirat
Projekte
Forschungsprojekte
Individuelle Varianten in der DNA-Sequenz (d.h. der linearen Abfolge der 4 DNA-Bausteine, der sog. Basen) werden als Polymorphismen bezeichnet und können die Funktion von Genen beeinflussen und so zur klinischen Manifestation von Krankheiten beitragen bzw. deren Verlauf und Therapie beeinflussen. Darüber hinaus können Polymorphismen-Muster für jedes Individuum so charakteristisch sein, dass sie auch die forensische Identifizierung von Tätern und Opfern anhand einer DNA-Spur ermöglichen.
Projektleitung an der H-BRS
Prof. Dr. Richard JägerPublikationen
Prof. Dr. Ralf Thiele
2023
Claudio Neidhöfer, Derick Lekealem Nkwetta, Bangsi Rose Fuen, Njodzeka Flora Yenban, Nancielle Mbiatong, Gordon Takop Nchanji, Patricia Korir, Nina Wetzig, Martin Sieber, Ralf Thiele, Marijo Parcina, Ute Klarmann-Schulz, Achim Hoerauf, Samuel Wanji, Manuel Ritter:
Tropical leg lymphedema caused by podoconiosis is associated with increased colonisation by anaerobic bacteria.
PDF Download (CC BY 4.0) doi:10.1038/s41598-023-40765-7 PMID urn:nbn:de:hbz:1044-opus-75099
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Claudio Neidhöfer, Maria Bagniceva, Nina Wetzig, Martin A. Sieber, Ralf Thiele, Marijo Parčina:
Pragmatic Considerations When Extracting DNA for Metagenomics Analyses of Clinical Samples.
PDF Download (CC BY 4.0) doi:10.3390/ijms241411262 urn:nbn:de:hbz:1044-opus-73988 PMID
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Mateja Condic, Claudio Neidhöfer, Damian J. Ralser, Nina Wetzig, Ralf Thiele, Martin Sieber, Lucia A. Otten, Leonie K. Warwas, Achim Hoerauf, Alexander Mustea, Marijo Parčina:
Analysis of the cervical microbiome in women from the German national cervical cancer screening program.
PDF Download (CC BY 4.0) doi:10.1007/s00432-023-04599-0 PMID urn:nbn:de:hbz:1044-opus-66298
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Sara-Sophie Poethe, Julia Holtel, Jan-Philip Biermann, Trine Riemer, Melanie Grabmüller, Burkhard Madea, Ralf Thiele, Richard Jäger:
Cost-Effective Next Generation Sequencing-Based STR Typing with Improved Analysis of Minor, Degraded and Inhibitor-Containing DNA Samples.
PDF Download (CC BY 4.0) doi:10.3390/ijms24043382 urn:nbn:de:hbz:1044-opus-66045 PMID
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Claudio Neidhöfer, Esther Sib, Al-Harith Benhsain, Christina Mutschnik-Raab, Anna Schwabe, Alexander Wollkopf, Nina Wetzig, Martin A. Sieber, Ralf Thiele, Manuel Döhla, Steffen Engelhart, Nico T. Mutters, Marijo Parčina:
Examining Different Analysis Protocols Targeting Hospital Sanitary Facility Microbiomes.
PDF Download (CC BY 4.0) doi:10.3390/microorganisms11010185 urn:nbn:de:hbz:1044-opus-65910 PMID
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2019
Jessica I. Hoell, Sebastian Ginzel, Michaela Kuhlen, Andreas Kloetgen, Michael Gombert, Ute Fischer, Daniel Hein, Salih Demir, Martin Stanulla, Martin Schrappe, Udo Zur Stadt, Peter Bader, Florian Babor, Friedhelm Schuster, Brigitte Strahm, Julia Alten, Anja Moericke, Gabriele Escherich, Arend von Stackelberg, Ralf Thiele, Alice C. McHardy, Christina Peters, Beat Bornhauser, Jean-Pierre Bourquin, Stefan Krause, Juergen Enczmann, Lüder Hinrich Meyer, Cornelia Eckert, Arndt Borkhardt, Roland Meisel:
Pediatric ALL relapses after allo-SCT show high individuality, clonal dynamics, selective pressure, and druggable targets.
doi:10.1182/bloodadvances.2019000051 PMID
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Sarah Aurora Heß, Jan-Philip Biermann, Melanie Grabmüller, Burkhard Madea, Ralf Thiele, Richard Jäger:
Evaluation of STR profiles of single telogen hairs using probabilistic methods.
doi:10.1016/j.fsigss.2019.10.049
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David Stahl, Andrew J. Gentles, Ralf Thiele, Ines Gütgemann:
Prognostic profiling of the immune cell microenvironment in Ewing´s Sarcoma Family of Tumors.
doi:10.1080/2162402x.2019.1674113 PMID
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D. Stahl, R. Thiele, A. J. Gentles, S. Schönberger, G. Kristiansen, I. Gütgemann:
Prognostic profiling of the immune cell microenvironment in Ewing sarcoma/PNET.
URL
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2018
Jessica I. Hoell, Sebastian Ginzel, Michaela Kuhlen, Andreas Klötgen, Michael Gombert, Ute Fischer, Daniel Schäfer, Martin Stanulla, Martin Schrappe, Udo zur Stadt, Peter Bader, Florian Babor, Friedhelm Schuster, Brigitte Strahm, Julia Alten, Anja Moericke, Gabriele Escherich, Arend von Stackelberg, Ralf Thiele, Alice C. McHardy, Christina Peters, Cornelia Eckert, Arndt Borkhardt, Roland Meisel:
Whole-Exome-Sequencing identifiziert hohe Plastizität, Selektionsdruck und „druggable targets“ in Leukämiezellen pädiatrischer ALL Rezidive nach allogener Stammzelltransplantation.
URL
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2016
Maria Joosten, Sebastian Ginzel, Christian Blex, Dmitri Schmidt, Michael Gombert, Cai Chen, René Martin Linka, Olivia Gräbner, Anika Hain, Burkhard Hirsch, Anke Sommerfeld, Anke Seegebarth, Uschi Gruber, Corinna Maneck, Langhui Zhang, Katharina Stenin, Henrik Dieks, Michael Sefkow, Carsten Münk, Claudia D. Baldus, Ralf Thiele, Arndt Borkhardt, Michael Hummel, Hubert Köster, Ute Fischer, Mathias Dreger, Volkhard Seitz:
A novel approach to detect resistance mechanisms reveals FGR as a factor mediating HDAC inhibitor SAHA resistance in B-cell lymphoma.
doi:10.1016/j.molonc.2016.06.001 PMID
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2015
Alberto Martin-Lorenzo, Julia Hauer, Carolina Vicente-Duenas, Franziska Auer, Ines Gonzalez-Herrero, Idoia Garcia-Ramirez, Sebastian Ginzel, Ralf Thiele, Stefan N. Constantinescu, Christoph Bartenhagen, Martin Dugas, Michael Gombert, Daniel Schafer, Oscar Blanco, Andrea Mayado, Alberto Orfao, Diego Alonso-Lopez, Javier de Las Rivas, Cesar Cobaleda, Maria Begona Garcia-Cenador, Francisco Javier Garcia-Criado, Isidro Sanchez-Garcia, Arndt Borkhardt:
Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of Pax5-Inherited Susceptibility.
doi:10.1158/2159-8290.CD-15-0892 PMID
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Schafiq Nabhani, Sebastian Ginzel, Hagit Miskin, Shoshana Revel-Vilk, Dan Harlev, Bernhard Fleckenstein, Andrea Hönscheid, Prasad T. Oommen, Michaela Kuhlen, Ralf Thiele, Hans-Jürgen Laws, Arndt Borkhardt, Polina Stepensky, Ute Fischer:
Deregulation of Fas ligand expression as a novel cause of autoimmune lymphoproliferative syndrome-like disease.
doi:10.3324/haematol.2014.114967 PMID
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Ute Fischer, Michael Forster, Anna Rinaldi, Thomas Risch, Stéphanie Sungalee, Hans-Jörg Warnatz, Beat Bornhauser, Michael Gombert, Christina Kratsch, Adrian M. Stütz, Marc Sultan, Joelle Tchinda, Catherine L. Worth, Vyacheslav Amstislavskiy, Nandini Badarinarayan, André Baruchel, Thies Bartram, Giuseppe Basso, Cengiz Canpolat, Gunnar Cario, Hélène Cavé, Dardane Dakaj, Mauro Delorenzi, Maria Pamela Dobay, Cornelia Eckert, Eva Ellinghaus, Sabrina Eugster, Viktoras Frismantas, Sebastian Ginzel, Oskar A. Haas, Olaf Heidenreich, Georg Hemmrich-Stanisak, Kebria Hezaveh, Jessica I. Höll, Sabine Hornhardt, Peter Husemann, Priyadarshini Kachroo, Christian P. Kratz, Geertruy Te Kronnie, Blerim Marovca, Felix Niggli, Alice C. McHardy, Anthony V. Moorman, Renate Panzer-Grümayer, Britt S. Petersen, Benjamin Raeder, Meryem Ralser, Philip Rosenstiel, Daniel Schäfer, Martin Schrappe, Stefan Schreiber, Moritz Schütte, Björn Stade, Ralf Thiele, Nicolas von der Weid, Ajay Vora, Marketa Zaliova, Langhui Zhang, Thomas Zichner, Martin Zimmermann, Hans Lehrach, Arndt Borkhardt, Jean-Pierre Bourquin, Andre Franke, Jan O. Korbel, Martin Stanulla, Marie-Laure Yaspo:
Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options.
doi:10.1038/ng.3362 PMID URL
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Cai Chen, Christoph Bartenhagen, Michael Gombert, Vera Okpanyi, Vera Binder, Silja Röttgers, Jutta Bradtke, Andrea Teigler-Schlegel, Jochen Harbott, Sebastian Ginzel, Ralf Thiele, Peter Husemann, Pina F.I. Krell, Arndt Borkhardt, Martin Dugas, Jianda Hu, Ute Fischer:
Next-generation-sequencing of recurrent childhood high hyperdiploid acute lymphoblastic leukemia reveals mutations typically associated with high risk patients.
doi:10.1016/j.leukres.2015.06.005 PMID
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2014
Schafiq Nabhani, Sebastian Ginzel, Hagit Miskin, Shoshana Revel-Vilk, Dan Harlev, Bernhard Fleckenstein, Andrea Höhnscheid, Prasad T. Oommen, Michaela Kuhlen, Ralf Thiele, Hans-Jürgen Laws, Arndt Borkhardt, Polina Stepensky, Ute Fischer:
Dysregulation of IL12 Signaling As a Novel Cause of an Autoimmune Lymphoproliferative like Syndrome.
doi:10.1182/blood.v124.21.1420.1420
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J. I. Hoell, M. Gombert, S. Ginzel, S. Loth, P. Landgraf, V. Käfer, M. Streiter, A. Prokop, M. Weiss, R. Thiele, A. Borkhardt:
Constitutional Mismatch Repair-deficiency and Whole-exome Sequencing as the Means of the Rapid Detection of the Causative MSH6 Defect.
doi:10.1055/s-0034-1389905 PMID
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2013
Y. Linka, S. Ginzel, M. Krüger, A. Novosel, M. Gombert, E. Kremmer, J. Harbott, R. Thiele, A. Borkhardt, P. Landgraf:
The impact of TEL-AML1 (ETV6-RUNX1) expression in precursor B cells and implications for leukaemia using three different genome-wide screening methods.
PDF Download (CC BY-NC-SA 3.0) doi:10.1038/bcj.2013.48 PMID urn:nbn:de:hbz:1044-opus-10394
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Cai Chen, Christoph Bartenhagen, Michael Gombert, Vera Okpanyi, Vera Binder, Andrea Teigler-Schlegel, Jutta Bradtke, Silja Roettgers, Jochen Harbott, Sebastian Ginzel, Ralf Thiele, Martin Dugas, Jianda Hu, Arndt Borkhardt, Ute Fischer:
Chromothripsis-Mediated Structural Variations and Clonal Evolution In Recurrent Childhood High Hyperdiploid Acute Lymphoblastic Leukemia.
doi:10.1182/blood.v122.21.233.233
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Cai Chen, Christoph Bartenhagen, Michael Gombert, Vera Okpanyi, Vera Binder, Silja Roettgers, Jutta Bradtke, Andrea Teigler-Schlegel, Jochen Harbott, Sebastian Ginzel, Ralf Thiele, Ute Fischer, Martin Dugas, Jianda Hu, Arndt Borkhardt:
Next-generation-sequencing-based risk stratification and identification of new genes involved in structural and sequence variations in near haploid lymphoblastic leukemia.
doi:10.1002/gcc.22054 PMID
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2012
Vera Okpanyi, Christoph Bartenhagen, Michael Gombert, Sebastian Ginzel, Pina Fanny Ida Krell, Peter Husemann, Cai Chen, Vera Binder, Jutta Bradtke, Andrea Teigler-Schlegel, Silja Roettgers, Jochen Harbott, Martin Stanulla, Cornelia Eckert, Ralf Thiele, Martin Dugas, Arndt Borkhardt, Ute Fischer:
Novel Genomic Structural Variations in Relapsed Childhood ETV6/RUNX1 (TEL/AML1) Acute Lymphoblastic Leukemias Identified by Next Generation Sequencing.
doi:10.1182/blood.V120.21.518.518
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2008
Robert Pesch, Artem Lysenko, Matthew Hindle, Keywan Hassani-Pak, Ralf Thiele, Christopher Rawlings, Jacob Köhler, Jan Taubert:
Graph-based sequence annotation using a data integration approach.
PDF Download (CC BY-NC-ND 3.0) doi:10.2390/biecoll-jib-2008-94 PMID doi:10.1515/jib-2008-94 urn:nbn:de:hbz:1044-opus-5283
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1999
Ralf Thiele, Ralf Zimmer, Thomas Lengauer:
Protein threading by recursive dynamic programming.
doi:10.1006/jmbi.1999.2893 PMID
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1998
Ralf Zimmer, Marko Wöhler, Ralf Thiele:
New scoring schemes for protein fold recognition based on Voronoi contacts.
doi:10.1093/bioinformatics/14.3.295 PMID
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1997
Ralf Zimmer, Ralf Thiele:
Fast protein fold recognition and accurate sequence-structure alignment.
doi:10.1007/BFb0033212
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1996
T. Lengauer, R. Thiele, R. Zimmer:
Modellierung von Proteinstrukturen.
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1995
Ralf Thiele, Ralf Zimmer, Thomas Lengauer:
Recursive Dynamic Programming for Adaptive Sequence and Structure Alignment.
PMID
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H. Schmidt, D. Theune, R. Thiele, T. Lengauer:
EMC-driven midway routing on PCBs.
doi:10.1109/EDTC.1995.470357
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1994
H. Mevissen, R. Thiele, R. Zimmer, T. Lengauer:
The ToPLign Software Environment - Toolbox for Preotein Alignment.
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D. Theune, R. Thiele, W. John, T. Lengauer:
Robust methods for EMC-driven routing.
doi:10.1109/43.329265
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1993
W. John, D. Theune, R. Thiele:
Layout design for printed-circuit boards under EMC-constraints.
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1992
Dirk Theune, Ralf Thiele, Thomas Lengauer, Anja Feldmann:
HERO: Hierarchical EMC-constrained routing.
doi:10.1109/ICCAD.1992.279326
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